Sequence analysis catRAPID signature: identification of ribonucleoproteins and RNA-binding regions

نویسندگان

  • Carmen Maria Livi
  • Petr Klus
  • Riccardo Delli Ponti
  • Gian Gaetano Tartaglia
چکیده

Motivation: Recent technological advances revealed that an unexpected large number of proteins interact with transcripts even if the RNA-binding domains are not annotated. We introduce catRAPID signature to identify ribonucleoproteins based on physico-chemical features instead of sequence similarity searches. The algorithm, trained on human proteins and tested on model organisms, calculates the overall RNA-binding propensity followed by the prediction of RNA-binding regions. catRAPID signature outperforms other algorithms in the identification of RNA-binding proteins and detection of non-classical RNA-binding regions. Results are visualized on a webpage and can be downloaded or forwarded to catRAPID omics for predictions of RNA targets. Availability and implementation: catRAPID signature can be accessed at http://s.tartaglialab.com/ new_submission/signature. Contact: [email protected] or [email protected] Supplementary information: Supplementary data are available at Bioinformatics online.

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catRAPID signature: identification of ribonucleoproteins and RNA-binding regions

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تاریخ انتشار 2016